S-5751
货号：
10004030-500ug 基本售价：
490.0 元 规格：
500 ug
产品信息
概述| 货号 | 10004030-500ug |
| 描述 | S-5751 is an antagonist of the prostaglandin D2(PGD2) receptor DP1(Ki = 1.6 nM) that shows at least 20-fold selectivity over receptors for thromboxane and prostacyclin, as well as the PGE2 receptor EP2.1,2 Orally administered S-5751 blocks PGD2-induced plasma exudation in the conjunctiva (ED50 = 0.099 mg/kg) and suppresses antigen-induced allergic responses in guinea pigs.1 S-5751 has been used to distinguish signaling of PGD2 through its two receptors, DP1 and DP2 (also known as CRTH2).3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Arimura, A.,Yasui, K.,Kishino, J., et al. Prevention of allergic inflammation by a novel prostaglandin receptor antagonist, S-5751. Journal of Pharmacology and Experimental Therapeutics 298(2), 411-419 (2001).
2.Tsuri, T.,Honma, T.,Hiramatsu, Y., et al. Bicyclo[2.2.1]heptane and 6,6-dimethylbicyclo[3.1.1]heptane derivatives: Orally active, potent, and selective prostaglandin D2 receptor antagonists. J. Med. Chem. 40(22), 3504-3507 (1997).
3.Choi, Y.H.,Lee, S.-N.,Aoyahi, H., et al. The extracellular signal-regulated kinase mitogen-activated protein kinase/ribosomal S6 protein kinase 1 cascade phosphorylates cAMP response element-binding protein to induce MUC5B gene expression via D-prostanoid receptor signaling. J. Biol. Chem. 286(39), 34199-33214 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 441.6 |
| 分子式 | C25H31NO4S |
| CAS号 | 209268-36-0 |
| 稳定性 | ≥ 2 years |
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