GW 501516
货号：
10004272-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 10004272-1mg |
| 描述 | Peroxisome proliferator-activated receptor δ (PPARδ) stimulation or over-expression in adipocytes leads to increased fatty acid oxidation, improved exercise tolerance, and resistance to obesity.1 GW 501516 is the first highly selective synthetic PPARδ agonist available. GW 501516 binds to human PPARδ with an IC50 value of 1 nM, and is at least 100-fold selective for PPARδ compared to PPARα and PPARγ.2 In obese primates, GW 501516 increases high density lipoprotein cholesterol and apolipoprotein A-1 specific reverse cholesterol transport.3 GW 501516 is therefore a model compound for a new type of obesity therapeutic, as well as a selective pharmacological tool for understanding lipid metabolism. |
| 别名 | GW 1516; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wang, Y.X.,Lee, C.H.,Tiep, S., et al. Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity. Cell 113, 159-170 (2003).
2.Sznaidman, M.L.,Haffner, C.D.,Maloney, P.R., et al. Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)-synthesis and biological activity. Bioorganic & Medicinal Chemistry Letters 13, 1517-1521 (2003).
3.Oliver, W.R.,Shenk, J.L.,Snaith, M.R., et al. A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport. Proceedings of the National Academy of Sciences of the United States of America 98(9), 5306-5311 (2001).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 453.5 |
| 分子式 | C21H18F3NO3S2 |
| CAS号 | 317318-70-0 |
| 稳定性 | ≥ 2 years |
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