14,15-EE-5(Z)-E
货号：
10004946-25ug 基本售价：
490.0 元 规格：
25 ug
产品信息
概述| 货号 | 10004946-25ug |
| 描述 | Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity.1 14,15-EE-5(Z)-E is a structural analog of 14,15-epoxyeicosatrienoic acids (14,15-EET) that antagonizes EET-induced relaxation of vascular smooth muscle.2 Relaxation of U46619-constricted bovine arteries by 14,15-EET could be inhibited approximately 80% by 14,15-EE-5(Z)-E at a concentration of 10 µM. 14,15-EE-5(Z)-E does not appear to antagonize nitric oxide- or iloprost-mediated vascular relaxation. |
| 别名 | 14,15-Epoxyeicosa-5(Z)-enoic Acid; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Fleming, I. Cytochrome P450 epoxygenases as EDHF synthase(s). Pharmacological Research 49, 525-533 (2004).
2.Gauthier, K.M.,Deeter, C.,Krishna, U.M., et al. 14,15-Epoxyeicosa-5(Z)-enoic acid: A selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries. Circulation Research 90, 1028-1036 (2002).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 324.5 |
| 分子式 | C20H36O3 |
| CAS号 | 519038-92-7 |
| 稳定性 | ≥ 1 year |
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