ABH
货号：
10006862-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 10006862-1mg |
| 描述 | L-Arginine serves as a common substrate for both nitric oxide synthase (NOS) and arginase in the cell. NOS catalyzes the oxidation of arginine to citrulline and NO with Nω-hydroxy-L-arginine formed as an intermediate. Arginase, on the other hand, catalyzes the hydrolysis of arginine into urea and L-ornithine. ABH is a slow-binding competitive inhibitor of human arginase II with Ki values of 0.25 µM and 8.5 nM at pH 7.5 and 9.5, respectively.1 ABH enhances both male and female sexual arousal responses in rabbits, an effect which may be due to increased NO bioavailability resulting from arginase inhibition.2 Inhibition of arginase is therefore a potential therapeutic target for the treatment of sexual arousal disorders. |
| 别名 | Amino-2-Borono-6-Hexanoic Acid; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Colleluori, D.M., and Ash, D.E. Classical and slow-binding inhibitors of human type II arginase. Biochemistry 40, 9356-9362 (2001).
2.Cama, E.,Colleluori, D.M.,Emig, F.A., et al. Human arginase II: Crystal structure and physiological role in male and female sexual arousal. Biochemistry 42, 8445-8451 (2003).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 175 |
| 分子式 | C6H14BNO4 |
| CAS号 | 222638-65-5 |
| 稳定性 | ≥ 1 year |
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