BCTC
货号：
10006309-5mg 基本售价：
462.0 元 规格：
5 mg
产品信息
概述| 货号 | 10006309-5mg |
| 描述 | The vanilloid receptor 1 (TRPV1) is a ligand-gated ion channel highly expressed on primary nociceptive neurons that respond to a variety of noxious stimuli, including heat, acid, and other chemical irritants. Because disruptions in TRPV1 activity cause reduced thermal nociception and hyperalgesia, this receptor is considered to be a useful target for the discovery of novel analgesics. BCTC is a potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 with IC50 values of 35 and 6 nM, respectively.1,2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Valenzano, K.J.,Grant, E.R.,Wu, G., et al. N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1 (2H)-carbox-amide (BCTC), a novel orally effective vanilloid receptor 1 antagonist with analgesic properties: I. In vitro characterization and pharmacokinetic properties. Journal of Pharmacology and Experimental Therapeutics 306(1), 377-386 (2003).
2.Gavva, N.R.,Tamir, R.,Klionsky, L., et al. Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1. Molecular Pharmacology 68(6), 1524-1533 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 372.9 |
| 分子式 | C20H25ClN4O |
| CAS号 | 393514-24-4 |
| 稳定性 | ≥ 2 years |
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