| 货号 | 10005765-5mg |
| 描述 | The endocannabinoids present a rich system of central cannabinoid (CB1), peripheral cannabinoid (CB2), and non-CB receptor-mediated pharmacology that has stimulated research in many fields including memory, weight loss and appetite, neurodegeneration, tumor surveillance, analgesia, and inflammation.1,2 Arachidoyl ethanolamide is one of the saturated fatty acyl ethanolamides devoid of classical (CB1/CB2) activity. Arachidoyl ethanolamide does not bind to the murine CB1receptor3 and does not compete with anandamide as a substrate for the endocannabinoid hydrolytic enzyme fatty acid amide hydrolase.4 Non-CB receptor-mediated pharmacology of the saturated ethanolamides is still being elucidated.5 |
| 别名 | N-Arachidoylethanolamine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Martin, B.R.,Mechoulam, R., and Razdan, R.K. Discovery and characterization of endogenous cannabinoids. Life Sciences 65, 573-595 (1999). 2.Pertwee, R.G. Pharmacology of cannabinoid receptor ligands. Current Medicinal Chemistry 6, 635-664 (1999). 3.Sheskin, T.,Hanus, L.,Slager, J., et al. Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor. Journal of Medicinal Chemistry 40, 659-667 (1997). 4.Desarnaud, F.,Cadas, H., and Piomelli, D. Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization. The Journal of Biological Chemisty 270(11), 6030-6035 (1995). 5.Smart, D.,Jonsson, K.O.,Vandevoorde, S., et al. “Entourage” effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism. British Journal of Pharmacology 136, 452-458 (2002). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 355.6 |
| 分子式 | C22H45NO2 |
| CAS号 | 94421-69-9 |
| 稳定性 | ≥ 2 years |
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