2,3-DCPE (hydrochloride)
货号：
10005229-5mg 基本售价：
406.0 元 规格：
5 mg
产品信息
概述| 货号 | 10005229-5mg |
| 描述 | 2,3-DCPE is a proapoptotic compound with selectivity for cancer cells versus normal human cells. It induces apoptosis in vitro in various cancer cell lines (IC50s = 0.89-2.69 µM) more effectively than in normal human fibroblasts (IC50 = 12.6 µM). 2,3-DCPE down-regulates Bcl-xL, however forced overexpression of Bcl-xL is sufficient to block 2,3-DCPE apoptosis induction.1 2,3-DCPE can induce S-phase arrest, upregulate p21, and activate ERK.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wu, S.,Zhu, H.,Gu, J., et al. Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol. Cancer Research 64, 1110-1113 (2004).
2.Zhu, H.,Zhang, L.,Wu, S., et al. Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl] amino]ethanol in correlation with activation of ERK. Oncogene 23, 4984-4992 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 300.6 |
| 分子式 | C11H15Cl2NO2 • HCl |
| CAS号 | 1009555-55-8 |
| 稳定性 | ≥ 2 years |
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