| 货号 | 10004675-50mg |
| 描述 | NADP+ is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate (NADPH, Item No. 9000743). It serves as a cofactor in various biological reactions.1,2 In addition, the balance between these reduced and oxidized forms plays key roles in diverse cellular functions, including cell survival, the maintenance of redox status, and intracellular signaling.2,3 For example, binding of NADP+ to β-subunits of Kv channels activates ion transport, whereas NADPH stabilizes channel inactivation.4NADP+ is biosynthesized from NAD+ (Item No. 16077) by NAD kinase, with ATP as the phosphoryl donor.5 |
| 别名 | Coenzyme II;β-NADP;Nicotinamide adenine dinucleotide phosphate;TPN; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Jackson, J.B. A review of the binding-change mechanism for proton-translocating transhydrogenase. Biochimica et Biophysica Acta 1817(10), 1839-1846 (2012). 2.Nakamura, M.,Bhatnagar, A., and Sadoshima, J. Overview of pyridine nucleotides review series. Circ. Res. 111(5), 604-610 (2012). 3.Ziegler, M. A vital link between energy and signal transduction: Regulatory functions of NAD(P). FEBS Journal 272(18), 4561-4564 (2014). 4.Kilfoil, P.J.,Tipparaju, S.M.,Barski, O.A., et al. Regulation of ion channels by pyridine nucleotides. Circ. Res. 112(4), 721-741 (2013). 5.Shi, F.,Li, Y.,Li, Y., et al. Molecular properties, functions, and potential applications of NAD kinases. Acta Biochim. Biophys. Sin. (Shanghai) 41(5), 352-361 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 837.5 |
| 分子式 | C21H27N7O17P3 • Na [4H2O] |
| 稳定性 | ≥ 2 years |
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