CAY10485
货号：
10006482-5mg 基本售价：
392.0 元 规格：
5 mg
产品信息
概述| 货号 | 10006482-5mg |
| 描述 | Acyl-coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis.1,2 CAY10485 inhibits human ACAT-1 and ACAT-2 with an IC50 values of 95 and 81 µM, respectively.3 It also inhibits copper-mediated oxidation of low density lipoproteins by 91% at a concentration of 2 µM.3 |
| 别名 | 3,4-dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Rudel, L.L.,Lee, R.G., and Cockman, T.L. Acyl coenzyme A: Cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis. Current Opinion in Lipidology 12, 121-127 (2001).
2.Lee, R.G.,Willingham, M.C.,Davis, M.A., et al. Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates. Journal of Lipid Research 41, 1991-2001 (2000).
3.Lee, S.,Han, J.M.,Kim, H., et al. Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA: Cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size. Bioorganic & Medicinal Chemistry Letters 14, 4677-4681 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 477.5 |
| 分子式 | C27H27NO7 |
| CAS号 | 615264-62-5 |
| 稳定性 | ≥ 2 years |
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