Leptomycin B
货号：
10004976-5ug 基本售价：
350.0 元 规格：
5 ug
产品信息
概述| 货号 | 10004976-5ug |
| 描述 | Leptomycin B is a potent inhibitor of the nuclear export of proteins. It directly blocks the interaction of CRM1 (exportin 1) with nuclear export signals (NES), preventing the export of a broad range of proteins.1 Leptomycin B will also indirectly inhibit the export of mRNA from the nucleus by blocking the nuclear export of mRNA-binding proteins (export factors).2 By blocking the nuclear export of p53, leptomycin B prevents entry of human normal fibroblasts into the S phase of the cell cycle, thus inhibiting proliferation.3 Leptomycin B was originally identified as an antifungal agent and is isolated from Streptomycessp.. |
| 别名 | Elactocin;LMB;Mantuamycin;NSC 364372; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kudo, N.,Wolff, B.,Sekimoto, T., et al. Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp. Cell Res. 242, 540-547 (1998).
2.Nishi, K.,Yoshida, M.,Fujiwara, D., et al. Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression. The Journal of Biological Chemisty 269(9), 6320-6324 (1994).
3.Smart, P.,Lane, E.B.,Lane, D.P., et al. Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin B. Oncogene 18, 7378-7386 (1999).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 540.7 |
| 分子式 | C33H48O6 |
| CAS号 | 87081-35-4 |
| 稳定性 | ≥ 1 year |
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