| 货号 | 10006611-1mg |
| 描述 | Farnesoid X receptor (FXR) is a nuclear receptor that acts as a bile acid sensor, protecting cells and organs against bile acid toxicity.1 GW 4064 is a selective agonist of FXR (EC50 = 15 nM).2 It displays no activity at other nuclear receptors, including the retinoic acid receptor, at concentrations up to 1 μM.2 GW 4064 is used to elucidate the role of FXR in dyslipidemia, diabetes, obesity, and cancer.3,4,5,6,7 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Rader, D.J. Liver X receptor and farnesoid X receptor as therapeutic targets. American Journal of Cardiology 100, 15N-19N (2007). 2.Maloney, P.R.,Parks, D.J.,Haffner, C.D., et al. Identification of a chemical tool for the orphan nuclear receptor FXR. Journal of Medicinal Chemistry 43(16), 2971-2974 (2000). 3.Haeusler, R.A.,Pratt-Hyatt, M.,Welch, C.L., et al. Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia. Cell Metabolism 15(1), 65-74 (2012). 4.Watanabe, M.,Horai, Y.,Houten, S.M., et al. Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure. The Journal of Biological Chemisty 286(30), 26913-26920 (2011). 5.Deuschle, U.,Schüler, J.,Schulz, A., et al. FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model. PLoS One 7(10), e43044 (2012). 6.Catalano, S.,Malvindi, R.,Giordano, C., et al. Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells. The Journal of Biological Chemisty 285(8), 5581-5593 (2010). 7.Cariou, B.,van Harmelen, K.,Duran-Sandoval, D., et al. The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice. The Journal of Biological Chemisty 281(16), 11039-11049 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 542.8 |
| 分子式 | C28H22Cl3NO4 |
| CAS号 | 278779-30-9 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |