(R)-Bromoenol lactone
货号：
10006800-500ug 基本售价：
350.0 元 规格：
500 ug
产品信息
概述| 货号 | 10006800-500ug |
| 描述 | The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components.1 The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). Unlike (S)-BEL, (R)-BEL does not inhibit iPLA2β except at high doses of 20-30 µM.2 (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 µM. |
| 别名 | (R)-BEL; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Balsinde, J.,Balboa, M.A.,Insel, P.A., et al. Regulation and inhibition of phospholipase A2. Annual Reviews of Pharmacology and Toxicology 39, 175-189 (1999).
2.Jenkins, C.M.,Han, X.,Mancuso, D.J., et al. Identification of calcium-independent phospholipase A2(iPLA2)β, and not iPLA2γ, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. The Journal of Biological Chemisty 277(36), 32807-32814 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 317.2 |
| 分子式 | C16H13BrO2 |
| CAS号 | 478288-90-3 |
| 稳定性 | ≥ 1 year |
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