| 货号 | 10006972-1mg |
| 描述 | AM281 is a potent and selective central cannabinoid (CB1) receptor antagonist/inverse agonist (Ki =12 nM and 4,200 nM for CB1 and CB2, respectively).1,2 Structurally, it is an analog of the CB1 inverse agonist rimonabant (Item No. 9000484).2 It has no effect on the vanilloid TRPV1 receptor.3 AM281 has been used to evaluate the potential effects of compounds at CB1.4,5 It has also been used to study the membrane localization and cycling of CB1.6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lan, R.,Lu, Q.,Fan, P., et al. Design and synthesis of the CB1 selective cannabinoid antagonist AM281: A potential human SPECT ligand. AAPS Pharmsci. 1(3), 1-7 (1999). 2.Gatley, S.J.,Lan, R.,Pyatt, B., et al. Binding of the non-classical cannabinoid CP 55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors. Life Sciences 61(14), PL-191-PL-197 (1997). 3.Jerman, J.C.,Gray, J.,Brough, S.J., et al. Comparison of effects of anandamide at recombinant and endogenous rat vanilloid receptors. British Journal of Anaesthesia 89(6), 882-887 (2002). 4.Baker, C.L., and McDougall, J.J. The cannabinomimetic arachidonyl-2-chloroethylamide (ACEA) acts on capsaicin-sensitive TRPV1 receptors but not cannabinoid receptors in rat joints. British Journal of Pharmacology 142, 1361-1367 (2004). 5.Brown, I.,Cascio, M.G.,Wahle, K.W.J., et al. Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines. Carcinogenesis 31(9), 1584-1591 (2010). 6.Leterrier, C.,Bonnard, D.,Carrel, D., et al. Constitutive endocytic cycle of the CB1 cannabinoid receptor. The Journal of Biological Chemisty 279(34), 36013-36021 (2004). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 557.2 |
| 分子式 | C21H19Cl2IN4O2 |
| CAS号 | 202463-68-1 |
| 稳定性 | ≥ 2 years |
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