CAY10487
货号：
10006480-5mg 基本售价：
308.0 元 规格：
5 mg
产品信息
概述| 货号 | 10006480-5mg |
| 描述 | The early stage of atherosclerosis is characterized by the aggregation of foam cells, so called a fatty streak, in the inner arterial wall. CAY10487 inhibits formation of fatty streak lesions of the thoracic aorta in high cholesterol-fed rabbits without affecting plasma lipid profiles or significantly inhibiting ACAT-1 or ACAT-2 activity.1,2 The percent area occupied by the atherosclerotic lesion in rabbits supplemented with 0.05% CAY10487 in the diet was 16.1% compared to 53.5% in control rabbits.1 CAY10487 also exhibits antioxidant activity, inhibiting copper-mediated oxidation of low-density lipoprotein by about 75% at a concentration of 2 µM.2 |
| 别名 | 3,4-Dihydrocinnamic Acid (L-alanine methyl ester) amide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lee, S.,Lee, C.H.,Oh, J.H., et al. Anti-atherogenic effects of 3,4-dihydroxy hydrocinnamides. Bioorganic & Medicinal Chemistry Letters 13, 2681-2682 (2003).
2.Lee, S.,Han, J.M.,Kim, H., et al. Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA: Cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size. Bioorganic & Medicinal Chemistry Letters 14, 4677-4681 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 265.3 |
| 分子式 | C13H15NO5 |
| CAS号 | 778624-05-8 |
| 稳定性 | ≥ 2 years |
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