Abnormal Cannabidiol
货号：
10004259-1mg 基本售价：
280.0 元 规格：
1 mg
产品信息
概述| 货号 | 10004259-1mg |
| 描述 | Traditionally, the activity of cannabinoid (CB) agonists was thought to be transduced by a pair of G protein-coupled receptors, CB1 and CB2.1 CAY10429 (abnormal cannabidiol) is a synthetic regioisomer of cannabidiol that fails to elicit either CB1 or CB2 responsiveness and is without psychotropic activity. CAY10429 induces endothelium-dependent vasodilation via a CB1/CB2/NO-independent mechanism.2 At a dose of 20 µg/g in rats, CAY10429 showed hypotensive activity that could not be antagonized by cannabidiol or SR141716A. CAY10429 is therefore believed to activate a third type of cannabinoid receptor, provisionally called the non-CB1/CB2 endocannabinoid receptor. CAY10429 also acts via these receptors to regulate the migratory activity of murine BV-2 microglial cells, with an EC50 of 600 nM.3 |
| 别名 | Abn-CBD;Abnormal Cannabidiol; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Felder, C.C.,Joyce, K.E.,Briley, E.M., et al. Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. Molecular Pharmacology 48, 443-450 (1995).
2.Járai, Z.,Wagner, J.A.,Varga, K., et al. Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. Proceedings of the National Academy of Sciences of the United States of America 96(24), 14136-14141 (1999).
3.Walter, L.,Franklin, A.,Witting, A., et al. Nonpsychotropic cannabinoid receptors regulate microglial cell migration. Journal of Neuroscience 23(4), 1398-1405 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 314.5 |
| 分子式 | C21H30O2 |
| CAS号 | 22972-55-0 |
| 稳定性 | ≥ 2 years |
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