PDM 11
货号：
10006341-10mg 基本售价：
280.0 元 规格：
10 mg
产品信息
概述| 货号 | 10006341-10mg |
| 描述 | The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin, benzo[a]pyrene, and numerous polyaromatics from soot and coal tar.1 PDM 11 is structurally very similar to several resveratrol analogs which act as a potent and selective AhR antagonists and agonists.2 One of these compounds, which contains fluorine in place of the 4-chlorine of PDM11, acts as a AhR antagonist with a Ki of approximately 3 nM.2 This fluorine-containing compound is inactive as a ligand for the estrogen receptor even at 100 µM. As AhR knockout mice are insensitive to the carcinogenic effects of classical AhR ligands, antagonists of AhR could potentially serve as therapeutic agents for the treatment for dioxin and other aryl hydrocarbon poisonings. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Denison, M.S., and Nagy, S.R. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annual Reviews of Pharmacology and Toxicology 43, 309-334 (2003).
2.de Medina, P.,Casper, R.,Savouret, J.F., et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. Journal of Medicinal Chemistry 48, 287-291 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 274.7 |
| 分子式 | C16H15ClO2 |
| CAS号 | 1032508-03-4 |
| 稳定性 | ≥ 2 years |
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