| 货号 | 10005276-5mg |
| 描述 | PDMP (Item No. 62595) is a ceramide analog first prepared in a search for inhibitors of glucosylceramide synthase.1 PDMP has two adjacent chiral centers (C1 and C2) allowing for the formation of four possible isomers. DL-threo PDMP contains two of these four stereoisomers; D-threo (1R,2R) and L-threo (1S,2S) PDMP. Treatment of cultured cells with PDMP reduces the synthesis of glucosylceramide, increases cellular ceramide, and induces cell cycle arrest.2 The ability to inhibit glucosylceramide synthase has been found to reside in the D-threo (1R,2R) enantiomer.3 Although the L-threo isomer lacks this activity, it may be responsible for some of the other pleiotropic effects of PDMP. By inhibiting β-1,4-galactosyltransferase 6, PDMP can also prevent the synthesis of lactosylceramide, a known promotor of neuroinflammation in mice during chronic experimental autoimmune encephalomyelitis, a model of multiple sclerosis.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Vunnam, R.R., and Radin, N.S. Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brain. Chemistry and Physics of Lipids 26, 265-278 (1980). 2.Rani, C.S.S.,Abe, A.,Chang, Y., et al. Cell cycle arrest induced by an inhibitor of glucosylceramide synthase. Correlation with cyclin-dependent kinases. The Journal of Biological Chemisty 270(6), 2859-2867 (1995). 3.Abe, A.,Radin, N.S.,Shayman, J.A., et al. Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth. Journal of Lipid Research 36, 611-621 (1995). 4.Mayo, L.,Trauger, S.A.,Blain, M., et al. Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation. Nature Medicine 20(10), 1147-1156 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 427 |
| 分子式 | C23H38N2O3 • HCl |
| CAS号 | 80938-69-8 |
| 稳定性 | ≥ 1 year |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |