| 货号 | 10005067-1mg |
| 描述 | 20-HETE is an important metabolite of arachidonic acid in the vasculature, especially in the kidney, where it is synthesized by cytochrome P450 (CYP450) enzymes of the 4A family.1,2 Alkylaryl imidazoles have been previously shown to inhibit certain CYP450 enzymes, including the CYP4A enzymes associated with 20-HETE synthesis.3 CAY10434 is a selective inhibitor of the 20-HETE synthase CYP4A11 exhibiting an IC50 value of 8.8 nM when tested in human renal microsomes.4 CAY10434 is nearly 200 times less potent as an inhibitor of 1A, 1C, and 3A CYP450 enzymes. |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Harder, D.R.,Lange, A.R.,Gebremedhin, D., et al. Cytochrome P450 metabolites of arachidonic acid as intracellular signaling molecules in vascular tissue. Journal of Vascular Research 34, 237-243 (1997). 2.Imig, J.D.,Zou, A.P.,Stec, D.E., et al. Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles. American Journal of Physiology 270, R217-R227 (1996). 3.Nakamura, T.,Sato, M.,Kakinuma, H., et al. Pyrazole and isoxazole derivatives as new, potent, and selective 20-hydroxy-5,8,11,14-eicosatetraenoic acid synthase inhibitors. Journal of Medicinal Chemistry 46, 5416-5427 (2003). 4.Nakamura, T.,Kakinuma, H.,Umemiya, H., et al. Imidazole derivatives as new potent and selective 20-HETE synthase inhibitor. Bioorganic & Medicinal Chemistry Letters 14, 333-336 (2004). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 287.4 |
| 分子式 | C17H25N3O |
| CAS号 | 769917-29-5 |
| 稳定性 | ≥ 1 year |
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