nor-NOHA (acetate)
货号：
10006861-1mg 基本售价：
238.0 元 规格：
1 mg
产品信息
概述| 货号 | 10006861-1mg |
| 描述 | L-Arginine serves as a common substrate for both nitric oxide synthase (NOS) and arginase in the cell. NOS catalyzes the oxidation of arginine to citrulline and NO with Nω-hydroxy-L-arginine (NOHA) formed as an intermediate. Arginase, on the other hand, catalyzes the hydrolysis of arginine into urea and L-ornithine. nor-NOHA (acetate) is a potent, reversible inhibitor of rat liver arginase with a Ki value of 0.5 µM, which is 20-fold lower than the Ki of 10 µM observed for NOHA.1 It is about 40-fold more potent than NOHA as an inhibitor of arginase from mouse macrophages, exhibiting an IC50 of 10-12 µM.2 nor-NOHA (acetate) is not a substrate for any of the 3 NOS isoforms and does not inhibit nNOS or iNOS.3,4 |
| 别名 | Nω-hydroxy-nor-Arginine; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Custot, J.,Moali, C.,Brollo, M., et al. A new α-amino acid N w -hydroxy-nor-L-arginine: A highly-affinity inhibitor of arginase well adapted to bind to its manganese cluster. Journal of the American Chemical Society 119, 4086-4087 (1997).
2.Tenu, J.P.,Lepoivre, M.,Moali, C., et al. Effects of the new arginase inhibitor N w -hydroxy-nor-L-arginine on NO synthase activity in murine macrophages. Nitric Oxide: Biology and Chemistry 3(6), 427-438 (1999).
3.Dijols, S.,Perollier, C.,Lefevre-Groboillot, D., et al. Oxidation of N w -hydroxyarginine analogues by NO-synthase: The simple, non amino acid N-butyl N-hydroxyguanidine is almost as efficient an NO precursor as N w -hydroxyarginine. Journal of Medicinal Chemistry 44(20), 3199-3202 (2001).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 296.3 |
| 分子式 | C5H12N4O3 • 2C2H4O2 |
| CAS号 | 1140844-63-8 |
| 稳定性 | ≥ 2 years |
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