SEW2871
货号：
10006440-10mg 基本售价：
238.0 元 规格：
10 mg
产品信息
概述| 货号 | 10006440-10mg |
| 描述 | Sphingosine-1-phosphate receptor 1 (S1P1) is one of five high affinity G protein-coupled S1P receptors which mediate a variety of effects including lymphocyte recirculation in the blood.1 Non-selective S1P receptor agonists, such as FTY720, produce clinical immunosuppression useful for preventing transplant rejection and treating autoimmune diseases. However, they also cause bradycardia by activating S1P3, the receptor responsible for regulation of heart rate.2 SEW2871 is a selective S1P1 receptor agonist in both human and mouse that is not active at the S1P2-5 receptors. SEW2871, therefore, suppresses the immune response by decreasing the number of lymphocytes circulating in blood without causing bradycardia.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kluk, M.J., and Hla, T. Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. Biochimica et Biophysica Acta 1582, 72-80 (2002).
2.Sanna, M.G.,Liao, J.,Jo, E., et al. Sphingosine 1-phosphate (S1P) receptor subtypes SIP1 and SIP3, respectively, regulate lymphocyte recirculation and heart rate. The Journal of Biological Chemisty 279(14), 13839-13848 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 440.4 |
| 分子式 | C20H10F6N2OS |
| CAS号 | 256414-75-2 |
| 稳定性 | ≥ 2 years |
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