NO-Indomethacin
货号：
10005705-1mg 基本售价：
224.0 元 规格：
1 mg
产品信息
概述| 货号 | 10005705-1mg |
| 描述 | NO-indomethacin is a hybrid molecule of indomethacin and a nitric oxide (NO) donor. This drug design combines the anti-inflammatory properties of a non-steroidal anti-inflammatory drug (NSAID) with the gastrointestinal protective effects of NO. Compounds of this class retain their anti-inflammatory and analgesic activity, but have reduced gastrointestinal and kidney toxicity compared to the NSAID alone.1 NO-indomethacin also enhances the cancer chemopreventative activity of indomethacin. NO-indomethacin exhibits an IC50 of 82 µM, compared to >1,000 µM for indomethacin alone, for the inhibition of pancreatic cancer cell (PaCa-2) growth after 24 hours in culture.2 |
| 别名 | NCX 2121; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wallace, J.F.,Elliott, S.N.,Del Soldato, P., et al. Gastrointestinal-sparing anti-inflammatory drugs: The development of nitric oxide-releasing NSAIDs. Drug Development Research 42, 144-149 (1997).
2.Kashfi, K.,Ryann, Y.,Qiao, L.L., et al. Nitric oxide-donating nonsteroidal anti-inflammatory drugs inhibit the growth of various cultured human cancer cells: Evidence of a tissue type-independent effect. Journal of Pharmacology and Experimental Therapeutics 303(3), 1273-1282 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 620.1 |
| 分子式 | C28H30ClN3O9S |
| CAS号 | 301838-28-8 |
| 稳定性 | ≥ 1 year |
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