| 货号 | 10004971-10g |
| 描述 | Epoxyeicosatrienoic acids (EETs), lipid mediators synthesized from arachidonic acid by cytochrome P-450 epoxygenases, are converted by soluble epoxide hydrolase (sEH) to the corresponding dihydroxyeicosatrienoic acids (DHETs). N,N’ Dicyclohexylurea (DCU) is a selective sEH inhibitor with IC50 values of 160 and 90 nM for recombinant human and mouse sEH, respectively.1 At 10 µM, DCU blocks the hydrolysis of cis- and trans-EETs by rat red blood cells and porcine coronary endothelial cells as well as completely inhibits 14,(15)-EET-induced PPARα activation.2,3,4 |
| 别名 | DCU;NSC 17013; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Morisseau, C.,Goodrow, M.H.,Dowdy, D., et al. Potent urea and carbamate inhibitors of soluble epoxide hydrolases. Proceedings of the National Academy of Sciences of the United States of America 96, 8849-8854 (1999). 2.Jiang, H.,Zhu, A.G.,Mamczur, M., et al. Hydrolysis of cis- and trans-epoxyeicosatrienoic acids by rat red blood cells. Journal of Pharmacology and Experimental Therapeutics 326, 330-337 (2008). 3.Fang, X.,Kaduce, T.L.,Weintraub, N.L., et al. Pathways of epoxyeicosatrienoic acid metabolism in endothelial cells. Implications for the vascular effects of soluble epoxide hydrolase inhibition. The Journal of Biological Chemisty 276(18), 14867-14874 (2001). 4.Fang, X.,Hu, S.,Xu, B., et al. 14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-α. American Journal of Physiology.Heart and Circulatory Physiology 290, H55-H63 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 224.3 |
| 分子式 | C13H24N2O |
| CAS号 | 2387-23-7 |
| 稳定性 | ≥ 2 years |
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