Tibolone
货号：
10006321-100mg 基本售价：
210.0 元 规格：
100 mg
产品信息
概述| 货号 | 10006321-100mg |
| 描述 | Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the treatment of osteoporosis.1 Three major metabolites of tibolone are responsible for its tissue selective mechanism of action. Conversion into 3α- and 3β-hydroxy-tibolone results in estrogenic effects in brain, vagina, and bone. The Δ4 isomer has progestrogenic and androgenic effects and does not cause estrogenic stimulation in the endometrium.1 A two-year longitudinal study indicates that low doses (1.25-2.5 mg) of tibolone effectively relieve climacteric symptoms and prevent loss of bone mass in early postmenopausal women.2 |
| 别名 | Livial;Liviella; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kloosterboer, H.J. Tissue-selectivity: The mechanism of action of tibolone. Maturitas 48, S30-S40 (2004).
2.Gambacciani, M.,Ciaponi, M.,Cappagli, B., et al. A longitudinal evaluation of the effect of two doses of tibolone on bone density and metabolism in postmenopausal women. Gynecological Endocrinology 18, 9-16 (2004).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 312.5 |
| 分子式 | C21H28O2 |
| CAS号 | 5630-53-5 |
| 稳定性 | ≥ 2 years |
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