QNZ
货号：
10006734-500ug 基本售价：
210.0 元 规格：
500 ug
产品信息
概述| 货号 | 10006734-500ug |
| 描述 | Nuclear factor-κB (NF-κB) is an ubiquitous transcription factor that functions to enhance the transcription of pro-inflammatory cytokines like TNF-α, IL-1β, IL-6, and IL-8.1 QNZ is an inhibitor of NF-κB activation with an IC50 of 11 nM in human Jurkat cells. It also inhibits TNF-α production from lipopolysaccharide-stimulated mouse splenocytes with an IC50 of 7 nM. QNZ showed efficacy in vivo by reducing edema formation in carrageenin-induced inflammation of rat hind paw.2 |
| 别名 | CAY10470; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Karin, M.,Yamamtoto, Y., and Wang, Q.M. The IKK NF-κB system: A treasure trove for drug development. Nature Reviews.Drug Discovery 3, 17-26 (2004).
2.Tobe, M.,Isobe, Y.,Tomizawa, H., et al. Discovery of quinazolines as a novel structural class of potent inhibitors of NF-κB activation. Bioorganic & Medicinal Chemistry 11, 383-391 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 356.4 |
| 分子式 | C22H20N4O |
| CAS号 | 545380-34-5 |
| 稳定性 | ≥ 2 years |
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