| 货号 | 10006995-1000mg |
| 描述 | Nitric Oxide (NO) is a free radical gas that is involved in a variety of biological processes including regulation vascular tone, neuronal signaling, and host defense.1,2 Nitroxyl (HNO) is the one electron reduced form of nitric oxide. Piloty’s acid is one of the best known and most widely used HNO donors. Under basic conditions Piloty’s acid decomposes to HNO and benzenesulfinate anion. The rate of HNO release at pH 7 is very slow (t½ = 5,500 minutes) making its use most effective above pH 8.0. The half-life of Piloty’s acid decreases with an increase in pH to 561, 90, and 33 minutes at pH 8.0, 9.0, and 10.0, respectively.3 Piloty’s acid also inhibits yeast aldehyde dehydrogenase with an IC50 or 48 µM.4 |
| 别名 | Benzenesulphonydroxamic Acid; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Beckman, J.S., and Koppenol, W.H. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and the ugly. American Journal of Physiology 271, C1424-C1437 (1996). 2.Bredt, D.S., and Snyder, S.H. Nitric oxide: A physiologic messenger molecule. Annual Reviews of Biochemistry 63, 175-195 (1994). 3.hughes, M.N., and Cammack, R. Synthesis, chemistry, and application of nitroxyl ion releasers sodium trioxodinitrate or Angeli’s Salt and Piloty’s Acid. Methods in Enzymology 301, 279-287 (1999). 4.Nagasawa, H.T.,Kawle, S.P.,Elberling, J.A., et al. Prodrugs of nitroxyl as potential aldehyde dehydrogenase inhibitors vis-à-vis vascular smooth muscle relaxants. Journal of Medicinal Chemistry 38, 1865-1871 (1995). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | >98% |
| 计算分子量 | 173.2 |
| 分子式 | C6H7NO3S |
| CAS号 | 599-71-3 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |