Oleyl Anilide
货号：
10006529-5mg 基本售价：
196.0 元 规格：
5 mg
产品信息
概述| 货号 | 10006529-5mg |
| 描述 | AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol.1 Oleyl analide (OA) is a weak inhibitor of acylCoA:cholesterol acyltransferase (ACAT) with an IC50 of 26 µM.2 OA and the related glyceride dioleoyl phenylamino propane 1,2-diol have been linked to a syndrome of eosinophilia, excessive T-cell activation, and elevated interleukin-4 (IL-4), soluble IL-2R, and IL-5. The clinical consequences are an acute pulmonary inflammatory reaction followed by chronic neuropathy, myalgia, and autoimmune connective tissue disease, generally referred to as toxic oil syndrome (TOS). Aniline-denatured cooking oil is a source of OA associated with TOS.3 |
| 别名 | OA;Oleic Acid Anilide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Suckling, K.E., and Stange, E.F. Role of acyl-CoA: Cholesterol acyltransferase in cellular cholesterol metabolism. Journal of Lipid Research 26, 647-671 (1985).
2.Roth, B.D.,Blankley, C.J.,Hoefle, M.L., et al. Inhibitors of acyl-CoA: Cholesterol acyltransferase. 1. Identification and structure-activity relationship of a novel series of fatty acid anilide hypocholesterolemic agents. Journal of Medicinal Chemistry 35, 1609-1617 (1992).
3.Gelpi, E.,de la Paz, M.P.,Terracini, B., et al. The spanish toxic oil syndrome 20 years after its onset: A multidisciplinary review of scientific knowledge. Environmental Health Perspectives 110(5), 457-464 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 357.6 |
| 分子式 | C24H39NO |
| CAS号 | 5429-85-6 |
| 稳定性 | ≥ 2 years |
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