| 货号 | 10006456-1mg |
| 描述 | Angiotensin II is a hormone that plays an important role in regulating blood pressure.1 Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1) receptor.2 Losartan is a mammalian AT1 receptor antagonist with a Ki value of 5-20 nM.3 In humans, losartan effectively controls hypertension while protecting renal function.4 Nitric oxide (NO) causes vasodilation and also inhibits platelet and neutrophil aggregation in the endothelium.5,6 NO-losartan A possesses similar anti-hypertensive effects to losartan, with the addition of the vasodilating effects of NO release.7 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ortiz, M.C.,Sanabria, E.,Manriquez, M.C., et al. Role of endothelin and isoprostanes in slow pressor responses to angiotensin II. Hypertension 37(2), 505-511 (2001). 2.Schiffrin, E.L. Beyond blood pressure: The endothelium and atherosclerosis progression. American Journal of Hypertension 15, 115S-122S (2002). 3.Ji, H.,Leung, M.,Zhang, Y., et al. Differential structural requirements for specific binding of nonpeptide and peptide antagonists to the AT1 angiotensin receptor. Identification of amino acid residues that determine binding of the antihypertensive drug losartan. J. Biol. Chem. 269(24), 16533-16536 (1994). 4.Caruso, D.,DAvino, M.,Acampora, C., et al. Effects of losartan and chlorthalidone on blood pressure and renal vascular resistance index in non-diabetic patients with essential hypertension and normal renal functions. J. Cardiovasc. Pharmacol. 44(5), 520-524 (2004). 5.Moncada, S., and Higgs, A. The L-arginine-nitric oxide pathway. New England Journal of Medicine 329, 2002-2012 (1993). 6.Loscalzo, J., and Welch, G. Nitric oxide and its role in the cardiovascular system. Progress in Cardiovascular Diseases 38, 87-103 (1995). 7.Breschi, M.C.,Calderone, V.,Digiacomo, M., et al. NO-sartans: A new class of pharmacodynamic hybrids as cardiovascular drugs. Journal of Medicinal Chemistry 47, 5597-5600 (2004). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 602 |
| 分子式 | C30H28ClN7O5 |
| CAS号 | 791122-48-0 |
| 稳定性 | ≥ 2 years |
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