| 货号 | 10006594-10mg |
| 描述 | Angiotensin II is a hormone that plays an important role in regulating blood pressure.1 Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1) receptor.2 Losartan is an AT1 receptor antagonist with a Ki value of 5-20 nM.3 It has an attenuating effect on vein graft atherosclerosis in rabbits and effectively reduces arterial blood pressure in rats.4,5 In humans, losartan controls hypertension while protecting renal function.6 |
| 别名 | DuP-753;MK 954; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ortiz, M.C.,Sanabria, E.,Manriquez, M.C., et al. Role of endothelin and isoprostanes in slow pressor responses to angiotensin II. Hypertension 37(2), 505-511 (2001). 2.Schiffrin, E.L. Beyond blood pressure: The endothelium and atherosclerosis progression. American Journal of Hypertension 15, 115S-122S (2002). 3.Ji, H.,Leung, M.,Zhang, Y., et al. Differential structural requirements for specific binding of nonpeptide and peptide antagonists to the AT1 angiotensin receptor. Identification of amino acid residues that determine binding of the antihypertensive drug losartan. J. Biol. Chem. 269(24), 16533-16536 (1994). 4.Ge, J.,Huang, D.,Liang, C., et al. Upregulation of lectinlike oxidized low-density lipoprotein receptor-1 expression contributes to the vein graft atherosclerosis: Modulation by losartan. Atherosclerosis 177(2), 263-268 (2004). 5.Xavier, F.E.,Rossoni, L.V.,Alonso, M.J., et al. Ouabain-induced hypertension alters the participation of enothelial factors in α-adrenergic responses differently in rat resistance and conductance mesenteric arteries. Br. J. Pharmacol. 143(1), 215-225 (2004). 6.Caruso, D.,DAvino, M.,Acampora, C., et al. Effects of losartan and chlorthalidone on blood pressure and renal vascular resistance index in non-diabetic patients with essential hypertension and normal renal functions. J. Cardiovasc. Pharmacol. 44(5), 520-524 (2004). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 461 |
| 分子式 | C22H23ClN6O • K |
| CAS号 | 124750-99-8 |
| 稳定性 | ≥ 2 years |
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