Sulindac
货号：
10004386-1000mg 基本售价：
126.0 元 规格：
1 g
产品信息
概述| 货号 | 10004386-1000mg |
| 描述 | Many non-steroidal anti-inflammatory drugs (NSAIDs) are potent but non-selective inhibitors of both COX-1 and COX-2 in humans.1 Sulindac is one of the older NSAIDs, an isostere of indomethacin developed before the inducible form of COX-2 was discovered.2 Although a number of NSAIDs have been found to protect against digestive tract cancers, sulindac has an extensive epidemiology documenting reduced human colorectal cancer. In murine models, sulindac was found not only to inhibit the enzymatic activity of polyp-associated COX-2, but also to downregulate the expression of colonic COX-2 protein to control levels.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Barnett, J.,Chow, J.,Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochimica et Biophysica Acta 1209, 130-139 (1994).
2.Shen, T.Y., and Winter, C.A. Chemical and biological studies on indomethacin, sulindac, and their analogs. Advances in Drug Research 12, 89-98 (1977).
3.Boolbol, S.K.,Dannenberg, A.J.,Chadburn, A., et al. Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis. Cancer Research 56, 2556-2560 (1996).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 356.4 |
| 分子式 | C20H17FO3S |
| CAS号 | 38194-50-2 |
| 稳定性 | ≥ 2 years |
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