| 货号 | 10005368-1000mg |
| 描述 | PPARα is a ligand-activated transcription factor involved in the regulation of lipid homeostasis.1,2 Activation of PPARα results in expression of a variety of genes, particularly those involved in fatty acid β-oxidation, binding, and transport.3 Fenofibrate is PPARα agonist and a member of a class of hypolipidemic drugs that includes clofibrate and benzafibrate, which have been used clinically to treat dyslipidemia and cardiovascular disease. In a transactivation assay, fenofibrate exhibits EC50 values of 18 and 30 µM for murine and human PPARα, respectively.4 It also binds to PPARγ, but with at least 10-fold less affinity and is inactive at PPARδ at concentrations up to 100 µM. |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Latruffe, N., and Vamecq, J. Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulators of lipid metabolism. Biochimie 79, 81-94 (1997). 2.Lemberger, T.,Desvergne, B., and Wahli, W. Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology. Annual Reviews of Cell Development and Biology 12, 335-363 (1996). 3.Mandard, S.,Müller, M., and Kersten, S. Peroxisome proliferator-activated receptor α target genes. Cellular and Molecular Life Sciences 61, 393-416 (2004). 4.Willson, T.M.,Brown, P.J.,Sternbach, D.D., et al. The PPARs: From orphan receptors to drug discovery. Journal of Medicinal Chemistry 43(4), 528-550 (2000). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 360.8 |
| 分子式 | C20H21ClO4 |
| CAS号 | 49562-28-9 |
| 稳定性 | ≥ 2 years |
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