DyLight™ 350 Phalloidin
货号：
12848S 基本售价：
4780.0 元 规格：
300units
产品信息
概述| 货号 | 12848S |
| 反应种属 | All |
| 应用 | IF-F/IF-IC |
| 使用方法 |
IF-IC () |
性能| 供应商 | CST |
| 背景 | Actin, a ubiquitous eukaryotic protein, is the major component of the cytoskeleton. At least six isoforms are known in mammals. Nonmuscle β- and γ-actin, also known as cytoplasmic actin, are predominantly expressed in nonmuscle cells, controlling cell structure and motility (1). Actin exists mainly as a fibrous polymer, F-actin. In response to cytoskeletal reorganizing signals during processes such as cytokinesis, endocytosis, or stress, cofilin promotes fragmentation and depolymerization of F-actin resulting in an increase in the monomeric globular form, G-actin (2). Phalloidin is a natually occuring toxic bicyclic peptide found in the deathcap toadstool, Amanita phalloides, that rapidly binds to F-actin with strong affinity (3).Actin是一种广泛存在的真核蛋白，也是细胞骨架的重要组成部分。在哺乳动物中至少六个亚型。Nonmuscleβγ-actin,也称为胞质肌动蛋白,主要在非肌肉细胞中表达，控制细胞结构和动力(1)。Actin主要以纤维聚合物也叫F-actin的形式存在。它主要响应细胞骨架重组信号在胞质分裂等过程,内吞作用,或应激反应,cofilin促进分裂和f -肌动蛋白解聚作用导致增加单体的球状G-actin形式(2)。Phalloidin是存在于羊肚菌中的天然有毒二环肽, Amanita phalloides能迅速与f -肌动蛋白结合，亲和力强(3)。 |
| 存放说明 | -20C |
参考图片Immunofluorescent analysis of HeLa cells using Cox IV (4D11-B3-E8) Mouse mAb #11967 (red) and ASH2L (D93F6) XP® Rabbit mAb #5019 (green). Actin filaments were labeled with DyLight™ 350 Phalloidin (blue).共聚焦免疫荧光分析HeLa细胞，使用的抗体是：Cox IV (4D11-B3-E8) Mouse mAb #11967（红色）和ASH2L (D93F6) XP® Rabbit mAb #5019（绿色），肌动蛋白纤维用DyLight™ 350 Phalloidin（蓝色）。 |
