| 货号 | 13752S |
| 供应商 | CST |
| 背景 | LKB1 (STK11) is a serine/threonine kinase and tumor suppressor that helps control cell structure, apoptosis and energy homeostasis through regulation of numerous downstream kinases (1,2). A cytosolic protein complex comprised of LKB1, putative kinase STRAD, and the MO25 scaffold protein, activates both AMP-activated protein kinase (AMPK) and several AMPK-related kinases (3). AMPK plays a predominant role as the master regulator of cellular energy homeostasis, controlling downstream effectors that regulate cell growth and apoptosis in response to cellular ATP concentrations (4). LKB1 appears to be phosphorylated in cells at several sites, including human LKB1 at Ser31/325/428 and Thr189/336/363 (5). |
| 存放说明 | 4C |
| 参考文献 | Baas, A.F. et al. (2004) Trends Cell Biol 14, 312-9. Marignani, P.A. (2005) J Clin Pathol 58, 15-9. Lizcano, J.M. et al. (2004) EMBO J 23, 833-43. Hardie, D.G. (2004) J Cell Sci 117, 5479-87. Sapkota, G.P. et al. (2002) Biochem J 362, 481-90. Jenne, D.E. et al. (1998) Nat Genet 18, 38-43. Sanchez-Cespedes, M. (2007) Oncogene 26, 7825-32. |
Immunohistochemical analysis of paraffin-embedded LNCaP (left) and A549 (right) cell pellets using LKB1 (D60C5F10) Rabbit mAb (IHC Formulated) #13031. |
