Mouse 4-1BB/TNFRSF9/CD137 (NP 035742) VersaClone cDNA (10 UG)
货号：
RDC1514 基本售价：
2825.6 元 规格：
10 ug
产品信息
概述| 货号 | RDC1514 |
| 别名 | 4-1BB ligand receptor; 4-1BB; CD137 antigen; CD137; CD137MGC2172; CDw137; FLJ43501; ILA; ILAhomolog of mouse 4-1BB; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; receptor protein 4-1BB; T cell antigen ILA; T-cell antigen 4-1BB homolog; T-cell antigen ILA; TNFRSF9; tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9 |
| 反应种属 | Mouse |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 3604 (Human); 21942 (Mouse); 500590 (Rat); 102127961 (Cynomolgus Monkey) |
| 背景 | 4-1BB, also known as CD137 and TNFRSF9, is a transmembrane TNF receptor superfamily member that is expressed as on various populations of activated T cell including CD4+, CD8+, memory CD8+, NKT, and regulatory T cells as well as on myeloid and mast cell progenitors, dendritic cells, mast cells, and bacterially infected osteoblasts. 4-1BB binding by 4-1BB Ligand costimulates T cell proliferation, activation, and/or survival and can enhance the activation-induced cell death of repetitively stimulated T cells. 4-1BB can associate with OX40 on activated T cells, forming a complex that responds to either ligand and inhibits Treg and CD8+ T cell proliferation. Reverse signaling through 4-1BB Ligand inhibits the development of dendritic cells, B cells, and osteoclasts but supports mature dendritic cell survival and costimulates the proliferation and activation of mast cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Adipogenesis Markers
- Co-stimulatory and Co-inhibitory Molecules
- Dendritic Cell Co-stimulatory Molecules
- Human CD Marker Products
- Regulation of Apoptosis by TNF Superfamily Members
- Regulation of B Cell Activation and Homeostasis by TNF Superfamily Members
- Regulation of Natural Killer Cell Co-stimulation by TNF Superfamily Members
- Regulation of T Cell Co-stimulation by TNF Superfamily Members
- Regulatory T Cells (Tregs)
- TNF Superfamily
- TNF Superfamily Receptors
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