Human B7-H4 (NP 078902) VersaClone cDNA (10 UG)
货号：
RDC0687 基本售价：
2825.6 元 规格：
10 ug
产品信息
概述| 货号 | RDC0687 |
| 别名 | B7h.5; B7-H4; B7H4T-cell costimulatory molecule B7x; B7S1; B7S1VCTN1; B7x; B7XPRO1291; FLJ22418; Immune costimulatory protein B7-H4; Protein B7S1; T cell costimulatory molecule B7x; V-set domain containing T cell activation inhibitor 1; V-set domain-containing T-cell activation inhibitor 1; Vtcn1 |
全称 | B7 Homolog 4 | | 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 79679 (Human); 242122 (Mouse) |
| 背景 | B7-H4, also known as B7x and B7S1, is an immune costimulatory protein that is expressed on the surface of activated lymphocytes, macrophages, monocytes, dendritic cells, epithelial cells, and bone marrow-derived mesenchymal stem cells. Its binding to activated T cells dampens T cell responses and induces cell cycle arrest in the T cell. Reverse signaling can induce either cell cycle arrest or apoptosis in the B7-H4 expressing cell. B7-H4 is upregulated in several carcinomas in correlation with tumor progression and metastasis. A soluble form of B7-H4 functions as a decoy molecule and is elevated in the serum of ovarian cancer, renal cell carcinoma, and rheumatoid arthritis patients. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Control of Immune Responses via CD28 and CTLA-4
- Co-stimulatory and Co-inhibitory Molecules
- Dendritic Cell Co-stimulatory Molecules
- Mini-review: B7 & CD28 Superfamilies
- Mini-review: B7 & CD28/CTLA-4 Receptor Families
- Mini-review: Dendritic Cell Maturation
- Mini-review: Immune Tolerance
- Mini-review: Th1/Th2
- Myeloid-derived Suppressor Cells (MDSC)
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