概述| 货号 | RDC1294 |
| 别名 | AAT5; activin A receptor type II-like kinase, 53kD; activin A receptor type II-like kinase, 53kDa; Activin receptor-like kinase 5; ACVRLK4; ALK-5; ALK-5ALK5; EC 2.7.11; EC 2.7.11.30; LDS1A; LDS2A; Serine/threonine-protein kinase receptor R4; SKR4; tbetaR-I; TGF-beta receptor type I; TGF-beta receptor type-1; TGF-beta type I receptor; TGFBR1; TGFR-1; transforming growth factor beta receptor I; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I (activin A receptor type II-likekinase, 53kD); Transforming growth factor-beta receptor type I |
全称 | Transforming Growth Factor beta Receptor I | | 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 7046 (Human); 21812 (Mouse); 29591 (Rat) |
| 背景 | Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70 - 85 kDa), and Type III (250 - 350 kDa). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. The Type II receptor is also a membrane-bound serine/threonine kinase that binds TGF-beta1 and TGF-beta 3 with high affinity and TGF-beta 2 with much lower affinity. The Type I and Type II receptors together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. The Type III receptor is a transmembrane proteoglycan with a large extracellular domain and a 43 amino acid residue cytoplasmic domain. The cytoplasmic domain of the Type III receptor lacks an obvious signaling motif and the receptor may not be involved directly in signal transduction. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Airway Inflammation and Remodeling
- Cancer Biomarkers
- Co-receptor Regulation of TGF-beta Signaling
- Cytokines and Receptors in Allergy and Asthma
- Cytokines and Receptors in Angiogenesis
- ICC / IHC Images: TGF-beta RI/ALK-5
- Interactive Pathway: TGF-beta Signaling Pathways
- Regulatory T Cells (Tregs)
- T Cell Cytokine Signaling
- Technical Notes: The Quantikine ELISA in Establishing a Role for Endoglin in Preeclampsia
- TGF-beta Family
- TGF-beta Superfamily
- Th17 Cells
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