Human HVEM/TNFRSF14 (NP 003811) VersaClone cDNA (10 UG)
货号：
RDC1360 基本售价：
2825.6 元 规格：
10 ug
产品信息
概述| 货号 | RDC1360 |
| 别名 | ATAR; CD270 antigen; CD270; CD40-like protein; Herpes virus entry mediator A; Herpesvirus entry mediator A; HveA; HVEMTR2HVEAATAR; LIGHTR; TNFRSF14; tumor necrosis factor receptor superfamily member 14; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entrymediator); Tumor necrosis factor receptor-like 2; tumor necrosis factor receptor-like gene2 |
全称 | Herpesvirus Entry Mediator | | 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 8764 (Human); 230979 (Mouse); 102137807 (Cynomolgus Monkey) |
| 背景 | HVEM/TNFRSF14 (herpesvirus entry mediator) is a transmembrane protein that is most highly expressed on naïve, memory, and regulatory T cells but declines during T cell activation. It is present at low levels on most resting leukocytes. HVEM is a receptor for BTLA, CD160, and LIGHT. A cis interaction between HVEM and BTLA promotes cell survival, while trans interaction promotes a state of lymphocyte inactivity. LIGHT is expressed following T cell activation and competes with BTLA for HVEM binding, leading to a proinflammatory response. The herpesvirus envelope glycoprotein gD, which binds HVEM to initiate membrane fusion, can antagonize both BTLA and LIGHT binding. Human, but not mouse, HVEM can also bind lymphotoxin-alpha. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - B Cell Development and Differentiation
- Co-stimulatory and Co-inhibitory Molecules
- Monocyte Markers
- Regulation of Apoptosis by TNF Superfamily Members
- Regulation of Natural Killer Cell Co-stimulation by TNF Superfamily Members
- Regulation of T Cell Co-stimulation by TNF Superfamily Members
- TNF Superfamily
- TNF Superfamily Receptors
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