概述| 货号 | RDC1115 |
| 别名 | CD254 antigen; CD254; ODF; OPGL; OPGLOPTB2; Osteoclast differentiation factor; Osteoprotegerin ligand; RANK L; RANKLreceptor activator of nuclear factor kappa B ligand; Receptor activator of nuclear factor kappa-B ligand; sOdf; TNF-related activation-induced cytokine; TNFSF11; TRANCEODFhRANKL2; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand superfamily member 11 |
全称 | TNF-related Activation-induced Cytokine | | 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 8600 (Human); 21943 (Mouse) |
| 背景 | TRANCE (TNF-related activation-induced cytokines), also known as RANK Ligand, OPGL, or ODF, is a TNF superfamily ligand produced by osteoblasts, bone marrow stromal cells, and activated T cells. It signals through RANK and is antagonized by the decoy receptor Osteoprotegerin. TRANCE stimulates bone resorption, is required for osteoclast differentiation, and is associated with the development of osteoporosis, vascular calcification, osteopetrosis, and progestin-induced breast cancer. It also mediates body temperature regulation and is essential for the development of a lactating mammary gland. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Activated T Cells Mediate Bone Loss Through OPGL/TRANCE
- Human CD Marker Products
- ICC / IHC Images: TRANCE/TNFSF11/RANK L
- Multiple Myeloma
- Osteoblast and Osteoclast Markers
- Osteoclast Co-stimulation
- Regulatory T Cells (Tregs)
- T Cell Cytokine Signaling
- TNF Superfamily
- TNF Superfamily Ligands
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