Human OX40/TNFRSF4 (NP 003318) VersaClone cDNA (10 UG)
货号：
RDC0360 基本售价：
2825.6 元 规格：
10 ug
产品信息
概述| 货号 | RDC0360 |
| 别名 | ACT-135; ACT35 antigen; ACT35ATC35 antigen; CD134 antigen; CD134; OX40 cell surface antigen; OX40 homologue; OX40L receptor; OX40lymphoid activation antigene ACT35; TAX transcriptionally-activated glycoprotein 1 receptor; tax-transcriptionally activated glycoprotein 1 receptor; TNFRSF4; tumor necrosis factor receptor superfamily member 4; tumor necrosis factor receptor superfamily, member 4; TXGP1LOX40 antigen |
| 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 7293 (Human); 22163 (Mouse); 25572 (Rat) |
| 背景 | OX40 (CD134; TNFRSF4) is a T cell costimulatory molecule of the TNF receptor superfamily that coordinates with other costimulators (CD28, CD40, CD30, CD27 and 4-1BB) to manage the activation of the immune response. OX40 is upregulated on antigen activated CD4+ and CD8+ T cells with costimulation by CD40-CD40 Ligand and CD28-B7. OX40 interactions with OX40 Ligand on antigen presenting cells enhances T cell survival, proliferation, and cytokine production. It also inhibits the conversion of effector T cells into regulatory T cells (Tregs) and can promote the maintenance of and recall response in memory T cells. OX40 is constitutively expressed on Tregs where it promotes Treg proliferation and immunosuppressive activity. OX40-OX40 Ligand signaling is involved in allergic airway inflammation, graft-versus-host disease, and autoimmune disease. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Co-stimulatory and Co-inhibitory Molecules
- Co-stimulatory Molecules Associated with Tfh Cells
- Human CD Marker Products
- Regulation of Apoptosis by TNF Superfamily Members
- Regulation of T Cell Co-stimulation by TNF Superfamily Members
- Regulatory T Cells (Tregs)
- TNF Superfamily
- TNF Superfamily Receptors
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