Human CD161 (NP 002249) VersaClone cDNA ( )
货号：
RDC1672 基本售价：
2825.6 元 规格：
10 ug
产品信息
概述| 货号 | RDC1672 |
| 别名 | CD161 antigen; CD161; CLEC5B; CLEC5BC-type lectin domain family 5 member B; HNKR-P1a; killer cell lectin-like receptor subfamily B member 1; killer cell lectin-like receptor subfamily B, member 1; KLRB1; Ly59; Natural killer cell surface protein P1A; NKR; NKRP1; NKR-P1; NKRP1A; NKR-P1AMGC138614; NKRP1ANKR |
| 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 3820 (Human) |
| 背景 | CD161, also known as KLRB1, NK1.1, and NKR-P1A is a 40 kDa type II transmembrane glycoprotein that contains one C-type lectin domain in its extracellular region. CD161 is expressed as a disulfide-linked dimer on the surface of Th17 cells and NK cells as well as on subsets of CD1-restricted T cells, intestinal NT cells, peripheral memory T cells, monocytes, and dendritic cells. It binds to OCIL/CLEC2d, leading to an inhibition of NK cell-mediated cytotoxicity and IFN-gamma secretion. Alternatively, CD161 can enhance TCR activation to CD1d ligation. CD161+ cell populations are depleted in ulcerative colitis, Graves disease, and AIDS, although CD161+ T cells are activated during asthmatic attacks. Additional related proteins are expressed in mouse but not human: the inhibitory NKR-P1B and D, and the stimulatory NKR-P1A, C, and F. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - C-type Lectin Family
- gamma delta T Cells
- Group 1 ILCs
- Group 2 ILCs
- Isolation, Culture, and Identification of Natural Killer Cells
- LTi Cells
- Natural Killer T (NKT) Cells
- NCR+ILC3
- Th17 Cells
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