概述| 货号 | RDC1137 |
| 别名 | CD215 antigen; CD215; IL-15 receptor subunit alpha; IL15RA; IL-15RA; IL-15R-alpha; interleukin 15 receptor, alpha; interleukin-15 receptor subunit alpha; MGC104179 |
全称 | Interleukin 15 Receptor alpha | | 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 3601 (Human); 16169 (Mouse) |
| 背景 | IL-15 Ra (Interleukin 15 Receptor alpha), also known as CD215, is a transmembrane glycoprotein that plays an important role in NK and CD8+ memory T cell homeostasis and activation. It transmits IL-15 induced signals and additionally interacts with a complex of IL-2 R beta and the common gamma chain (gammaC) which are also subunits of the IL-2 receptor complex. In transpresentation, IL-15/IL-15 Ra complexes are expressed on the surface of one cell and interact with complexes of IL-2 R beta/gammaC on adjacent cells. IL-15/IL-15 Ra complexes can transmit reverse signaling that promotes adhesion and activation of the IL-15/IL-15 Ra expressing cells. Shed soluble forms of IL-15 Ra retain the ability to bind tightly to IL-15 and can inhibit IL-15 bioactivity. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Common gamma Chain Receptor Family
- Group 1 ILCs
- ICC / IHC Images: IL-15 R alpha
- Interactive Pathway: IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types
- Interactive Pathway: IL-15 Signaling Pathways
- Isolation, Culture, and Identification of Natural Killer Cells
- Mini-review: Interleukin 15 (IL-15)
- Natural Killer T (NKT) Cells
- Receptors in the Jak/STAT Pathway
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