| 货号 | RDC0896 |
| 别名 | CD123 antigen; CD123; hIL3Ra; hIL-3Ra; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL3R; IL3RA; IL-3RA; IL-3R-alpha; IL3RAY; IL3RX; IL3RY; interleukin 3 receptor, alpha (low affinity); interleukin-3 receptor subunit alpha; MGC34174 | 全称 | Interleukin 3 Receptor alpha |
| 反应种属 | Human |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 3563 (Human); 16188 (Mouse) |
| 背景 | Interleukin 3 (IL-3) is a pleiotropic cytokine that can stimulate proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. IL-3 exerts its activity through binding to a specific cell surface receptor known as IL-3 R. IL-3 R is a heterodimeric structure composed of a 70 kDa IL-3 R alpha subunit (CD123 or beta common) and a 120-140 kDa IL-3 R beta subunit (CD131). CD131 also associates with the receptor for Erythropoietin, forming a tissue-protective hetero-receptor complex. IL-3 R alpha binds IL-3 with relatively low affinity. In the presence of IL-3 R beta, however, IL-3 R alpha has a much higher affinity for IL-3. It is not clear how signal transduction occurs following IL-3 binding. The IL-3 R alpha chain has a very short intracellular domain while the IL-3 R beta chain has a very large cytoplasmic domain. Recent studies suggest that formation of IL-3 R beta-beta homodimers initiates signaling events. The IL-3 R beta chain is also shared by the receptors for IL-5 and GM-CSF. Cells known to express IL-3 receptors include hematopoietic progenitors, epithelial cells, double negative T cells, mast cells, basophils and blood monocytes. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
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