Human CD47 (NP 001768) VersaClone cDNA (10 UG)
货号：
RDC1523 基本售价：
2825.6 元 规格：
10 ug
产品信息
概述| 货号 | RDC1523 |
| 别名 | antigen identified by monoclonal 1D8; Antigenic surface determinant protein OA3; CD47 antigen (Rh-related antigen, integrin-associated signal transducer); CD47 antigen; CD47 glycoprotein; CD47 molecule; CD47; IAP; IAPintegrin associated protein; Integrin-associated protein; leukocyte surface antigen CD47; MER6integrin-associated signal transducer; OA3; Protein MER6; Rh-related antigen |
| 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 961 (Human); 16423 (Mouse) |
| 背景 | CD47, also known as Integrin-Associated Protein (IAP) and OA3, is a ubiquitous transmembrane protein that binds to SIRP family members on macrophages, neutrophils, and T cells. These interactions prevent macrophage-mediated clearance of healthy CD47-expressing cells and promote immune cell transmigration across the vascular endothelium. CD47 associates in cis with Fas on T cells and enhances Fas-mediated apoptosis; its ligation promotes T cell anergy and dampens Th1 immune responses. CD47 also associates in cis with several Integrins?which can positively or negatively modulate Integrin-mediated function. CD47 binding by Thrombospondin-1 inhibits the angiogenic and vasorelaxant effects of nitric oxide. On dendritic cells and myeloma cells, CD47 ligation by TSP-1 induces giant cell formation and osteoclast differentiation. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Acute Myeloid Leukemia
- Cancer Stem Cell Markers
- Dendritic Cell Pathogen Recognition/Uptake
- Endothelial Cell Markers and Adhesion Molecules in Angiogenesis
- Human CD Marker Products
- ICC / IHC Images: CD47
- Immunoglobulin Superfamily CAMs
- Integrins and Associated Molecules
- Lymphoma
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