Human CD1d (NP 001757) VersaClone cDNA (10 UG)
货号：
RDC1193 基本售价：
2825.6 元 规格：
10 ug
产品信息
概述| 货号 | RDC1193 |
| 别名 | antigen-presenting glycoprotein CD1d; CD1A; CD1d antigen; CD1D antigen, d polypeptide; CD1d molecule; CD1d; differentiation antigen CD1-alpha-3; HMC class I antigen-like glycoprotein CD1D; MGC34622; R3; R3G1; T-cell surface glycoprotein CD1d; thymocyte antigen CD1D |
| 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 912 (Human); 12480 (Mouse); 25109 (Rat) |
| 背景 | CD1d1 is a 48 kDa transmembrane glycoprotein in the CD1 family of glycolipid antigen-presenting MHC-like molecules. Complexes of CD1d1 with beta 2-microglobulin and endogenous glycolipids are constitutively expressed on antigen presenting cells, cortical thymocytes, liver sinusoidal endothelial cells, Kupffer cells, and hepatocytes. CD1d1-presented glycolipids are recognized by canonical NKT cells that utilize an invariant mouse V alpha 14-J alpha 18 chain in their T cell receptor (V alpha 24-J alpha 18 in human). The interaction with glycolipid-loaded CD1d1 is critical for NKT cell development and induces their rapid secretion of both Th1 and Th2 type cytokines. In humans, infection with HSV-1 suppresses NKT cell activation by blocking the intracellular cycling of CD1d1 in antigen presenting cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - B Cell Markers
- Epithelial Cell Markers and Intracellular Molecules
- Myeloid-derived Suppressor Cells (MDSC)
- Surface Ectodermal Cells
- T Cell Antigen Recognition
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