概述| 货号 | RDC0857 |
| 别名 | AI314697; GP130; IL11RA; IL-11RA; Il11ra2; NR1 |
全称 | Interleukin 11 Receptor alpha | | 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 3590 (Human); 16157 (Mouse) |
| 背景 | IL-11 Ra (Interleukin-11 receptor alpha) is a widely expressed transmembrane protein that associates with gp130 to form a functional receptor complex for the cytokine IL-11. gp130 also functions as a subunit in the receptors for Cardiotrophin-1, CNTF, IL-6, IL-27, IL-31, LIF, and Oncostatin M. IL-11 Ra plays a role in female reproduction and the survival of oligodendrocytes and colonic epithelial cells. It enhances osteoclast differentiation and bone remodeling but inhibits adipocyte differentiation. Soluble IL-11 Ra confers IL-11 responsiveness to cells expressing gp130, while in cells expressing transmembrane IL-11 Ra and gp130, soluble IL-11 Ra acts as an IL-11 antagonist. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Cytokines and Receptors in Allergy and Asthma
- IL-6 Family
- Obesity
- Receptors in the Jak/STAT Pathway
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