概述| 货号 | RDC0383 |
| 别名 | 6530402N02Rik; anterior pharynx defective 1 homolog A (C. elegans); APH-1; APH-1A; aph-1alpha; CGI-78; gamma-secretase subunit APH-1A; Presenilin-stabilization factor; PSF |
全称 | gamma-Secretase Subunit Anterior Pharynx Defective 1 Homolog A | | 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 51107 (Human); 100039623 (Mouse) |
| 背景 | Anterior pharynx-defective 1 (APH1A) is a widely expressed 36 kDa 7-transmembrane protein found in the endoplasmic reticulum and Golgi. APH1A is a component of the gamma secretase proteolytic complex which cleaves multiple substrates within their transmembrane domains. This activity liberates the intracellular domains of ErbB4, Neuregulin-1, and Notch receptors in addition to the A-beta peptide from the amyloid precursor protein (APP). Alternate splicing generates a short isoform of human APH1a that lacks 18 amino acids at the C-terminus. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - APP Cleavage and Amyloid-beta Degradation
- Aspartic Proteases and Regulators
- Cell to Cell Adhesion Disassembly During EMT
- ICC / IHC Images: APH1A
- Notch Family
- Notch Pathway
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