概述| 货号 | RDC0248 |
| 别名 | 5HT4; 5-HT-4; 5-HT4R; 5-hydroxytryptamine (serotonin) receptor 4,5-hydroxytryptamine receptor 4,5-HT45-hydroxytryptamine4 receptor; cardiac 5-HT4 receptor; HTR4; Serotonin receptor 4 |
全称 | 5-Hydroxytryptamine Receptor 4 | | 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 3360 (Human) |
| 背景 | 5HT4R, also known as HTR4, is an approximately 45 kDa multipass serotonin receptor that is expressed in the brain, gastrointestinal tract, bladder, vascular endothelial cells, atrium, kidney, and adrenal gland. It is involved in the regulation of learning, memory, anxiety, smooth muscle contraction, and adrenal corticosteroid secretion. Alternate splicing of human 5HT4R generates multiple isoforms with either a 14 aa insertion in the second extracellular loop or a deletion or various substitutions in the C-terminal cytoplasmic region. Different isoforms show tissue specific expression patterns or increased activity in the absence of ligand. Human 5HT4R shares 94% and 88% aa sequence identity with mouse and rat 5HT4R, respectively. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Neurotransmitter G Protein-Coupled Receptors
- Platelets
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