| 货号 | RDC0899 |
| 别名 | GABA(A) receptor subunit alpha-5; GABRA5; gamma-aminobutyric acid (GABA) A receptor, alpha 5; gamma-aminobutyric acid receptor subunit alpha-5; MGC138184 | 全称 | gamma-Aminobutyric Acid Type A Receptor, alpha-5 Polypeptide |
| 反应种属 | Human |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 2558 (Human); 110886 (Mouse); 29707 (Rat) |
| 背景 | GABA A (γ-aminobutyric acid-type A) receptors are members of the cysteine-loop family of neurotransmitter-gated ion channels. GABA binding to A-type receptors induces anion-selective ion channel opening. These receptors are the principal fast inhibitory neurotransmitter receptors in the CNS. GABA A receptors are heteropentamer combinations of seven subunit types; α, β, γ, δ, ε, θ, and π. Three subunits, α, β, and γ, have at least three separate gene products in mammals, and typical GABA A receptors have some combination of α, β, and γ subunits. The rat α5 isoform is a 439 amino acid (aa), 4 transmembrane protein with two terminal extracellular regions. The ligand-binding region is in the N-terminus (aa 25 - 232). The α5 subunit is unusual in that it contains an N-terminal histidine which renders it very sensitive to zinc. It is also associated with extrasynaptic sites and seems to mediate tonic inhibition in hippocampal neurons. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 |
|