概述| 货号 | RDC0299 |
| 别名 | G protein-coupled receptor 4; GPR19; G-protein coupled receptor 19; G-protein coupled receptor 4 |
全称 | G Protein-coupled Receptor 4 | | 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 2828 (Human); 319197 (Mouse); 308408 (Rat) |
| 背景 | The activation of GPR4, a proton-sensing G protein-coupled receptor, by isocapnic acidosis increases the adhesiveness of human umbilical vein endothelial cells (HUVECs) that express GPR4 endogenously. Acidosis in combination with GPR4 overexpression further augments HUVEC adhesion with U937 monocytes. Activation of GPR4 increases the expression of vascular adhesion molecules E-selectin, VCAM-1 and ICAM-1, which are functionally involved in acidosis/GPR4-mediated HUVEC adhesion. Acidosis/GPR4 signaling regulates endothelial cell adhesion mainly through the G(s)/cAMP/Epac pathway and may play a role in the inflammatory response of vascular endothelial cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
