概述| 货号 | RDC1192 |
| 别名 | CD1; CD1a antigen; CD1A antigen, a polypeptide; CD1a molecule; CD1a; cluster of differentiation 1 A; cortical thymocyte antigen CD1A; differentiation antigen CD1-alpha-3; epidermal dendritic cell marker CD1a; FCB6; hTa1 thymocyte antigen; HTA1; R4; T6; T-cell surface antigen T6/Leu-6; T-cell surface glycoprotein CD1a |
全称 | T Cell Surface Glycoprotein CD1a | | 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 909 (Human) |
| 背景 | Cluster of Differentiation 1a (CD1a) is a transmembrane glycoprotein in the CD1 family of MHC-like molecules. It is expressed by most mammals but not by mice or rats. Human CD1a is a 311 amino acid protein with a predicted molecular mass of 49 kDa. It binds to lipid and glycolipid antigens and presents them to T cells. Antigen-presenting cells, Langerhans cells, and thymocytes express CD1a, where it traffics between endosomes and plasma membrane lipid rafts. Heterodimerization with beta-2-Microglobulin is required for CD1a membrane trafficking, and CD1a binding to exogenous lipids results in CD1a protein stability. The activation of thymus-localized T cells during the development of Graves’ disease and Hashimoto’s thyroiditis may be initiated by CD1a expressed by CD83+ dendritic cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Conventional/Classical Dendritic Cells
- Epithelial Cell Markers and Intracellular Molecules
- ICC / IHC Images: CD1a
- Inflammatory/Monocyte-derived Dendritic Cells
- Langerhans and Dermal Dendritic Cells
- Plasmacytoid Dendritic Cells
- Surface Ectodermal Cells
- T Cell Antigen Recognition
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