概述| 货号 | RDC0307 |
| 别名 | G protein-coupled receptor 20; G-protein coupled receptor 20 |
全称 | G Protein-coupled Receptor 20 | | 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 2843 (Human); 239530 (Mouse); 60667 (Rat) |
| 背景 | GPR20 is constitutively active in the absence of ligand, leading to continuous activation of its coupled G proteins. When GPR20 was exogenously expressed in HEK293 cells, both the basal level and the prostaglandin E(2)-induced production of cAMP were significantly decreased. Knockdown of GPR20 in PC12h cells resulted in an elevation of the basal cAMP level, suggesting that the endogenous GPR20 achieves a constitutively or spontaneously active conformation. GPR20 may be involved in cellular processes, including control of intracellular cAMP levels and mitogenic signaling. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Orphan G Protein-Coupled Receptors
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